Description of the Brokken–Wiersinga–Prummel loop:
Normal values
The structural parameters for the Brokken–Wiersinga–Prummel loop. Standard value for GT. No other parameters are changed.
Hypothyroid
The structural parameters for the Brokken–Wiersinga–Prummel loop. Value for GT: 1E-13. No other parameters are changed.
Thyrotoxicosis
The structural parameters for the Brokken–Wiersinga–Prummel loop. Value for GT: 2E-10. No other parameters are changed.
Note the differences in the patterns, particularly varying effects of ultrashort-loop feedback parameters SS and DS with respect to different functional states (GT) of the overall feedback control system (1.). NOTE NOT EXACT NUMBERS!
| Trend | Hypothyroid | Standard | Thyrotoxicosis | ||
| secretory capacity of the thyroid gland | GT | \ | – 8,5 -> + 12 | – 7 -> + 9,5 | -6 -> + 8 |
| secretory capacity of the pituitary gland | GH | U | – 10,5 -> + 9,3 | – 9 -> + 8 | – 10,3 -> + 9 |
| damping constant of TRH (anterior pituitary) | DH | U | – 7,8 -> + 10 | -6,6 -> 8,2 | – 7,5 -> + 9,8 |
| brake constant of Brokken–Wiersinga–Prummel feedback loop | SS | \ | – 8 -> + 11 | – 6 -> 7,8 | – 4 -> + 4,5 |
| damping constant of TSH (anterior pituitary) | DS | \ | – 8,2 -> 7,8 | – 7 -> 6 | – 5 -> + 3,9 |
- Midgley JEM,Hoermann R, Larisch R,et al.J Clin Pathol Published Online First: [May 12, 2016] doi:10.1136/jclinpath-2012-201213