KM 2

KM 2: dissociation constant of type 2 deiodinase

TABLE 8.1 Decrease KM 2 ( /10 ) 1E-10 STANDARD FIGURES Increase KM 2 (x10) 1E-8
TRH 2500 2500 2500
TSH 0.7204 1,8 4.9344
TT4 63.6932 121,94 197.0175
FT4 9.2296 17,67 28.5491
TT3 1.6798 3,21 5.1956
FT3 2.7949 5,35 8.6450
cT3 56908.1934 11693,7490 1917.2921
KM 2 increase
basis
Standard values
KM 2 decrease

Explain dissociation constants: In chemistry, biochemistry, and pharmacology, a dissociation constant () is a specific type of equilibrium constant that measures the propensity of a larger object to separate (dissociate) reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into its component ions. The dissociation constant is the inverse of the association constant. In the special case of salts, the dissociation constant can also be called an ionization constant

GD 2

GD 2: Sum activity of central type 2 deiodinase (D2)

TABLE 8. Decrease GD2 ( /10 ) 4.3E-16 STANDARD FIGURES Increase GD2 (x10) 4.3E-14
TRH 2500 2500 2500
TSH 4.9923 1,8 0.6974
TT4 197.8387 121,94 62.0698
FT4 28.6681 17,67 8.9943
TT3 5.2173 3,21 1.6369
FT3 8.6810 5,35 2.7237
cT3 11693.7408 11693,7490 11693.7408

Changes in this parameter affects not only the T3 values but also TSH and the T4 values. Simulated values shown here:

basis