Two parameters may change the value of FT3 in the mathematical model (Ref.1);
k423 – positive feedforward of TSH and FT4 onto FT3 (downstream, activating)
a4 – the FT3 elimination rate constant.
Only examples of the effect of the parameter –
- Hoermann R, Pekker MJ, Midgley JEM, Larisch R and Dietrich JW (2022) Principles of Endocrine Regulation: Reconciling Tensions Between Robustness in Performance and Adaptation to Change. Front. Endocrinol. 13:825107. doi: 10.3389/fendo.2022.825107 https://www.frontiersin.org/articles/10.3389/fendo.2022.825107/full